Immuno-Biomolecular Engineering × Lab

Columbia University

Engineering next-generation biomolecular immunotherapies

We integrate protein engineering, synthetic biology, and biomaterials to address challenges in cancer and infectious diseases, engineering RNA- and protein-based platforms that precisely modulate immune responses and improve therapeutic efficacy.

Our approach

Where disciplines meet

Synthetic biology

RNA-based gene circuits that sense and respond to their environment.

Protein engineering

Designer proteins that precisely modulate immune responses.

Biomaterials

Engineered biopolymers for controlled, depot-forming delivery.

Biomolecular engineering

RNA- and protein-based platforms for next-generation therapeutics.

Research

Three core research areas

01

RNA circuits for the tumor microenvironment

Rewiring immunosuppressive tumors into inflammatory ones.

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02

Controlled-release vaccines

Single-dose vaccines that mimic natural infection.

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03

Harnessing endogenous mechanisms

Therapies that work with the body’s own processes.

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Visit us

Find the lab

Yousefpour Lab
Columbia University
Mary Woodard Lasker Biomedical Research Building, Room 516
3960 Broadway, New York, NY 10032

Contact

Get in touch

Parisa Yousefpour, Principal Investigator
py2339 [at] columbia [dot] edu

Interested in joining? We are recruiting postdocs, graduate students, and undergraduates. See open positions →

Mary Woodard Lasker Biomedical Research Building, Columbia University